Antimicrobial resistance patterns of Haemophilus influenzae isolated from patients with meningitis in São Paulo, Brazil.
Braz J Med Biol Res
; 33(3): 295-300, 2000 Mar.
Article
en En
| MEDLINE
| ID: mdl-10719380
From 1989 to 1995, a total of 391 Haemophilus influenzae isolates were recovered from the cerebrospinal fluid (CSF) of hospitalized patients in São Paulo, Brazil. The majority of strains were isolated from infants aged less than 5 years. Strains belonging to biotype I (64.7%), biotype II (34.5%) and biotype IV (0.76%) were detected. Ninety-nine percent of these strains were serotype b. Minimal inhibitory concentration (MIC) was determined for ampicillin, chloramphenicol and ceftriaxone. The ss-lactamase assay was performed for all strains. The rate of ss-lactamase producer strains ranged from 10 to 21.4% during a period of 7 years, with an overall rate of 13.8%. Of the 391 strains analyzed, none was ss-lactamase negative ampicillin resistant (BLNAR). A total of 9.7% of strains showed resistance to both ampicillin and chloramphenicol; however, 4% of them were resistant to ampicillin only and 2% to chloramphenicol. All strains were susceptible to ceftriaxone and the MIC90 was 0.007 microg/ml, suggesting that ceftriaxone could be an option for the treatment of bacterial meningitis in pediatric patients who have not been screened for drug sensitivity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Haemophilus influenzae
/
Meningitis por Haemophilus
/
Antibacterianos
Límite:
Child
/
Child, preschool
/
Humans
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Braz J Med Biol Res
Año:
2000
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil