Localization of calcitonin receptor mRNA in the mouse brain: coexistence with serotonin transporter mRNA.
Brain Res Mol Brain Res
; 76(1): 93-102, 2000 Mar 10.
Article
en En
| MEDLINE
| ID: mdl-10719219
To elucidate the sites of and mechanisms of analgesic effect of centrally injected calcitonin, we examined expression of calcitonin receptor mRNA in the mouse brain by in situ hybridization techniques. Calcitonin receptor mRNA was expressed in various brain regions, including the preoptic area, dorsomedial hypothalamic nucleus, lateral hypothalamic area, periaqueductal gray, dorsal raphe nucleus, locus coeruleus, lateral parabrachial nucleus, gigantocellular reticular nucleus alpha part, lateral paragigantocellular nucleus, raphe magnus nucleus and solitary tract nucleus, which are known to play important roles in pain modulation. In addition, a double in situ hybridization technique demonstrated the intense expression of calcitonin receptor mRNA on serotonergic neurons in some raphe nuclei and the lateral paragigantocellular nucleus, suggesting the involvement of central serotonergic pathways in analgesic effect of calcitonin.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Membrana
/
Encéfalo
/
ARN Mensajero
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Glicoproteínas de Membrana
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Proteínas Portadoras
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Serotonina
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Receptores de Calcitonina
/
Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Revista:
Brain Res Mol Brain Res
Asunto de la revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Países Bajos