Relevance of locoregional chemotherapy in patients with liver metastases from colorectal primaries.
Swiss Surg
; 6(1): 11-22, 2000.
Article
en En
| MEDLINE
| ID: mdl-10709432
Progression of colorectal cancer can occur primarily isolated in the liver. But, only the minority of the affected patients is eligible for surgery. Initially, systemic chemotherapy was ineffective in the treatment of unresectable hepatic metastases. For this reason, intraarterial chemotherapy was introduced as treatment alternative to the systemic chemotherapy. Long-term intraarterial chemotherapy regimens with FUDR in patients with colorectal liver metastases, using implantable pumps and ports, resulted in improved response rates, which was confirmed by several randomized trials. However, an improvement in median survival has not yet been demonstrated after regional chemotherapy of hepatic metastases. Since the intraarterial therapy with floxuridine (FUDR) had been reported to result in a high rate of local toxicity, 5-fluorouracil (5-FU) was introduced into regional chemotherapy of the liver. A randomized trial demonstrated superiority of intraarterial 5-FU versus intraarterial FUDR therapy. Despite these reports about high response rates, the benefit of intraarterial chemotherapy remains questionable, because it has not yet resulted in a prolongation of median survival. For this reason, long-term regional chemotherapy cannot be considered as standard treatment and should therefore not be conducted outside controlled clinical trials. Further evaluations on this technique should only be performed in experienced centers.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infusiones Intraarteriales
/
Neoplasias Colorrectales
/
Floxuridina
/
Fluorouracilo
/
Neoplasias Hepáticas
/
Antimetabolitos Antineoplásicos
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Swiss Surg
Año:
2000
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Suiza