E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro.

Owens, D W; Brunton, V G; Parkinson, E K; Frame, M C

Owens, D W; Brunton, V G; Parkinson, E K; Frame, M C.

Afiliación

Owens DW; Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, United Kingdom.

Biochem Biophys Res Commun ; 269(2): 369-76, 2000 Mar 16.

Article en En | MEDLINE | ID: mdl-10708559

RESUMEN

The origin of the signal for keratinocyte differentiation is still unknown. Here, we show that Ca(2+)- and density-induced translocation of E-cadherin, but not P-cadherin, is accompanied by induction of differentiation-specific proteins in cultured keratinocytes. Antibodies that artificially cluster cell-surface E-cadherin in low extracellular Ca(2+) also induce differentiation-specific proteins, implicating E-cadherin as a determinant of keratinocyte differentiation in vitro.

Asunto(s)

Cadherinas/metabolismo; Diferenciación Celular; Queratinocitos/citología; Calcio/metabolismo; Adhesión Celular; Comunicación Celular; Células Cultivadas; Humanos; Queratinocitos/enzimología; Queratinocitos/metabolismo; Precursores de Proteínas/metabolismo; Transglutaminasas/metabolismo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadherinas / Queratinocitos / Diferenciación Celular Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2000 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

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