Interlaboratory study comparing the microbiological potency of spiramycins I, II and III.
J Pharm Biomed Anal
; 20(1-2): 217-24, 1999 Jun.
Article
en En
| MEDLINE
| ID: mdl-10704026
An interlaboratory study has been performed to determine the relative potencies of spiramycins (SPMs) I, II and III by diffusion or/and turbidimetric assays with Bacillus subtilis or Staphylococcus aureus as the test organisms. Six laboratories from three countries participated. Experimental procedures were according to the European Pharmacopoeia, 3rd ed. The activity of SPM I is markedly higher than that of SPM II and III. By diffusion, the activities of SPM II and III relative to SPM I were found to be 57 and 72%, respectively. The interlaboratory relative standard deviations (RSD) varied from 3.6 to 16.3%. By turbidimetry, the activities of SPM II and III relative to SPM I were found to be 45 and 52%, respectively. The interlaboratory RSD values varied from 2.6 to 7.7%. The results of the study were analyzed according to the ISO 5725-2 guidelines to determine the repeatability, the between-laboratory and the reproducibility variances of both methods.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espiramicina
/
Aminoglicósidos
/
Antibacterianos
Idioma:
En
Revista:
J Pharm Biomed Anal
Año:
1999
Tipo del documento:
Article
País de afiliación:
Bélgica
Pais de publicación:
Reino Unido