Effect of an antioxidant (quercetin) on sodium-lauryl-sulfate-induced skin irritation.
Contact Dermatitis
; 42(2): 85-9, 2000 Feb.
Article
en En
| MEDLINE
| ID: mdl-10703630
Quercetin is a bioflavonoid with antioxidant and anti-inflammatory activity. The purpose of this study was to examine the effect of quercetin on acute skin irritation, with special interest in the skin barrier function recovery. Acute irritant contact dermatitis was induced in 15 patients by 24-h occlusion of 2% sodium lauryl sulfate (SLS) (day (D) 1). The influence of application on SLS-irritated skin of topical quercetin for 5 consecutive Ds, compared to vehicle and controls, was studied. Parameters measured were transepidermal water loss (TEWL) and erythema index. Final measurements were taken on D 7 after a 1-D rest period. TEWL and the erythema index continued to rise 2 D after application of SLS and 1 D after treatment with quercetin, vehicle or controls. Both TEWL and erythema values at D 7 did not return to values before the SLS barrier disruption at all the test sites. Therefore, quercetin topically applied after induction of irritant contact dermatitis does not appear to increase the recovery of barrier function and erythema caused by SLS.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quercetina
/
Dodecil Sulfato de Sodio
/
Tensoactivos
/
Dermatitis Irritante
/
Irritantes
/
Antiinflamatorios
/
Antioxidantes
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Contact Dermatitis
Año:
2000
Tipo del documento:
Article
País de afiliación:
Grecia
Pais de publicación:
Reino Unido