Effects of dialyser and dialysate on the acute phase reaction in clinical bicarbonate dialysis.
Nephrol Dial Transplant
; 15(3): 379-84, 2000 Mar.
Article
en En
| MEDLINE
| ID: mdl-10692524
BACKGROUND: In chronic haemodialysis (HD), morbidity may result from repetitive induction of the acute phase response, caused by a bioincompatible dialysis membrane and/or contaminated dialysate. In the present study, cytokine release (interleukin-6, IL-6) and subsequent production of acute phase proteins (C-reactive protein, CRP and secretory phospholipase A(2), sPLA(2)) were assessed to investigate whether the HD-induced acute phase reaction depends mainly on the type of membrane or on the sterility of the dialysate. METHODS: In 11 patients, IL-6, CRP and sPLA(2) levels were assessed in blood samples drawn before (t(0)), at the end (t(180)) and 24 h after the start of HD (t(1440)). All patients were dialysed on Cuprammonium (CU) and Polysulphon (PS) dialysers and seven patients underwent an additional HD session on CU plus a dialysate filter (CUf). RESULTS: IL-6 levels were increased significantly at t(180) compared with t(0) (P<0.02) with both CU and CUf. At t(1440), IL-6 levels had returned to baseline. In contrast, marked fluctuations did not occur during HD with PS. At t(180), IL-6 was significantly greater with CU and CUf devices, than with PS (P<0.02). Following HD with CU and CUf, a significant increase in CRP was observed at t(1440), compared with postdialysis values (P
Asunto(s)
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bicarbonatos
/
Soluciones para Diálisis
/
Diálisis Renal
/
Reacción de Fase Aguda
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Nephrol Dial Transplant
Asunto de la revista:
NEFROLOGIA
/
TRANSPLANTE
Año:
2000
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Reino Unido
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bicarbonatos
/
Soluciones para Diálisis
/
Diálisis Renal
/
Reacción de Fase Aguda
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Nephrol Dial Transplant
Asunto de la revista:
NEFROLOGIA
/
TRANSPLANTE
Año:
2000
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Reino Unido