Correlation between cytochrome P-450 CYP2D6 (CYP2D6) genotype and phenotype.

Chen, S Q; Wedlund, P J

Chen, S Q; Wedlund, P J.

Afiliación

Chen SQ; Department of Biochemistry, College of Medicine, Zhejiang University, Hangzhou, China.

Zhongguo Yao Li Xue Bao ; 20(7): 585-8, 1999 Jul.

Article en En | MEDLINE | ID: mdl-10678117

RESUMEN

AIM: To study the correlation between CYP2D6 genotype and its phenotype. METHODS: CYP2D6 genotyping was made by detecting CYP2D6*3, *4, *6, and *7 alleles with an allele-specific polymerase chain reaction procedure. RESULTS: The CYP2D6 genotypes were well correlated with its phenotypes in all 125 extensive metabolizers and in 43 poor metabolizers. Extensive metabolizers had at least one wildtype CYP2D6 gene and the genotypes were *1/*1, *1/*3, and *1/*4. Poor metabolizers were found to be homozygous mutants of CYP2D6 gene and the genotypes were *3/*4, *4/*4, *3/*6, *4/*7, *4/*6, and *6/*6. CONCLUSION: Genotype could be used to screen variations of CYP2D6 expression.

Asunto(s)

Citocromo P-450 CYP2D6/genética; Adulto; Alelos; Citocromo P-450 CYP2D6/clasificación; Femenino; Genotipo; Humanos; Masculino; Persona de Mediana Edad; Fenotipo; Reacción en Cadena de la Polimerasa

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocromo P-450 CYP2D6 Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Zhongguo Yao Li Xue Bao Año: 1999 Tipo del documento: Article País de afiliación: China Pais de publicación: China

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