Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial.
Lancet
; 355(9201): 352-7, 2000 Jan 29.
Article
en En
| MEDLINE
| ID: mdl-10665554
ABSTRACT
PIP: This double-blind, randomized, controlled study investigated the efficacy, safety and tolerability of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria among Gambian children. Combined use of artesunate and pyrimethamine-sulphadoxine was hypothesized to delay or prevent resistance, which proved to be effective in reducing childhood mortality in sub-Saharan Africa. A total of 600 children with acute uncomplicated Plasmodium falciparum malaria, 6 months to 10 years old, were randomly administered pyrimethamine-sulphadoxine (25 mg/500 mg) with placebo, 4 mg/kg body weight pyrimethamine-sulphadoxine plus 1 dose of artesunate, or pyrimethamine-sulphadoxine plus 4 mg/kg body weight artesunate for 3 days. Results indicate that combined treatment was well tolerated. On day 1, 178 of 381 children treated with artesunate were still parasitemic compared with 157 of 195 children in the pyrimethamine-sulphadoxine group. On the other hand, failure rates on day 14 were 3.1% in the pyrimethamine-sulphadoxine group and 3.7% in the 1-dose artesunate group and 1.6% in the 3-dose group. Insignificant differences were found among children administered 1-dose and 3-dose artesunate, and were found less likely to be gametocytemic after treatment. In conclusion, this study confirms the safety and efficacy of a combined treatment, which eventually results in lower gametocyte rates and lower transmission rates.
Palabras clave
Africa; Africa South Of The Sahara; Age Factors; Child; Demographic Factors; Developing Countries; Diseases; Double-blind Studies; Drugs; English Speaking Africa; Gambia; Malaria; Parasitic Diseases; Population; Population Characteristics; Research Methodology; Research Report; Studies; Treatment; Western Africa; Youth
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirimetamina
/
Sesquiterpenos
/
Sulfadoxina
/
Malaria Falciparum
/
Artemisininas
/
Antimaláricos
Tipo de estudio:
Clinical_trials
/
Etiology_studies
Límite:
Animals
/
Child
/
Child, preschool
/
Female
/
Humans
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Infant
/
Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
Lancet
Año:
2000
Tipo del documento:
Article
Pais de publicación:
Reino Unido