Isolation and structures of schleicherastatins 1-7 and schleicheols 1 and 2 from the teak forest medicinal tree Schleichera oleosa.

Pettit, G R; Numata, A; Cragg, G M; Herald, D L; Takada, T; Iwamoto, C; Riesen, R; Schmidt, J M; Doubek, D L; Goswami, A

Pettit, G R; Numata, A; Cragg, G M; Herald, D L; Takada, T; Iwamoto, C; Riesen, R; Schmidt, J M; Doubek, D L; Goswami, A.

Afiliación

Pettit GR; Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-2404, USA.

J Nat Prod ; 63(1): 72-8, 2000 Jan.

Article en En | MEDLINE | ID: mdl-10650082

RESUMEN

Bioassay (P-388 lymphocytic leukemia cell line)-guided separation of an extract prepared from the bark and stem of the Sri Lankan tree Schleichera oleosa led to the isolation of seven cancer cell growth inhibitory hydroxylated sterols designated schleicherastatins 1-7 (1-7) and two related sterols, schleicheols 1 and 2 (8, 9). The structure of schleicherastatin 1 (1) was completely elucidated by X-ray crystal structure determination. Based upon that defined structure, the remaining new sterol structures were deduced by highfield (300 and 500 MHz) NMR and MS interpretations. In this new series of sterols, hydroxylation at C-22 appears to be important for promoting cancer cell growth inhibition.

Asunto(s)

Antineoplásicos Fitogénicos/aislamiento & purificación; Plantas Medicinales/química; Esteroles/aislamiento & purificación; Árboles/química; Antineoplásicos Fitogénicos/química; Estructura Molecular; Análisis Espectral; Esteroles/química; Células Tumorales Cultivadas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Esteroles / Árboles / Antineoplásicos Fitogénicos Idioma: En Revista: J Nat Prod Año: 2000 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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