Your browser doesn't support javascript.
loading
Age-dependent changes in lipid peroxide levels in peripheral organs, but not in brain, in senescence-accelerated mice.
Matsugo, S; Kitagawa, T; Minami, S; Esashi, Y; Oomura, Y; Tokumaru, S; Kojo, S; Matsushima, K; Sasaki, K.
Afiliación
  • Matsugo S; Department of Chemical and Biochemical Engineering and CREST, Faculty of Engineering, Toyama University, Japan.
Neurosci Lett ; 278(1-2): 105-8, 2000 Jan 07.
Article en En | MEDLINE | ID: mdl-10643812
The tissue concentration of lipid peroxides was determined in the brain, heart, liver, lung and kidney of accelerated senescence-prone (SAMP-8) and -resistant (SAMR-1) mice at 3, 6 and 9 months of age by a method involving chemical derivatization and high performance liquid chromatography. The level of lipid peroxides in the brain did not show an age-dependent change, but at each age the brain level of lipid peroxides was significantly higher in SAMP-8 than in SAMR-1. In contrast, the lipid peroxide levels in the peripheral organs showed increases with aging in both strains, and they were significantly higher in SAMP-8 than in SAMR-1 at both 3 and 6 months of age (except at 3 months of age in the kidney). These results suggest that increased oxidative stress in the brain and peripheral organs is a cause of the senescence-related degeneration and impairments seen in SAMP-8.
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Encefálica / Peroxidación de Lípido / Envejecimiento Prematuro Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2000 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Encefálica / Peroxidación de Lípido / Envejecimiento Prematuro Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2000 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda