Age-dependent changes in lipid peroxide levels in peripheral organs, but not in brain, in senescence-accelerated mice.
Neurosci Lett
; 278(1-2): 105-8, 2000 Jan 07.
Article
en En
| MEDLINE
| ID: mdl-10643812
The tissue concentration of lipid peroxides was determined in the brain, heart, liver, lung and kidney of accelerated senescence-prone (SAMP-8) and -resistant (SAMR-1) mice at 3, 6 and 9 months of age by a method involving chemical derivatization and high performance liquid chromatography. The level of lipid peroxides in the brain did not show an age-dependent change, but at each age the brain level of lipid peroxides was significantly higher in SAMP-8 than in SAMR-1. In contrast, the lipid peroxide levels in the peripheral organs showed increases with aging in both strains, and they were significantly higher in SAMP-8 than in SAMR-1 at both 3 and 6 months of age (except at 3 months of age in the kidney). These results suggest that increased oxidative stress in the brain and peripheral organs is a cause of the senescence-related degeneration and impairments seen in SAMP-8.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Química Encefálica
/
Peroxidación de Lípido
/
Envejecimiento Prematuro
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Irlanda