Self-administration of intravenous amphetamine: effect of nucleus accumbens CCKB receptor activation on fixed-ratio responding.
Psychopharmacology (Berl)
; 147(3): 331-4, 1999 Dec.
Article
en En
| MEDLINE
| ID: mdl-10639694
RATIONALE: The mesolimbic dopamine (DA) system is implicated in psychostimulant drug self-administration. The neuropeptide cholecystokinin (CCK) is co-localised with DA and inhibits nucleus accumbens (NAcc) DAergic neurotransmission via CCKB receptors. OBJECTIVES: The present experiment was designed to examine the effects of intra-NAcc CCKB receptor stimulation on fixed-ratio (FR) amphetamine self-administration. METHODS: Wistar rats with intravenous catheters and NAcc cannulae were trained to self-administer amphetamine under a FR3 schedule of reinforcement. Animals performing stable self-administration were microinjected with pentagastrin and assessed during 3-h sessions. RESULTS: Intra-NAcc pentagastrin dose dependently increased amphetamine intake. CONCLUSIONS: These results are consistent with the notion that NAcc CCKB receptor activation attenuates amphetamine reward.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Colecistoquinina
/
Condicionamiento Operante
/
Dextroanfetamina
/
Estimulantes del Sistema Nervioso Central
/
Núcleo Accumbens
Límite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
1999
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Alemania