The relaxant activity of the methanolic extract of Acanthus montanus on intestinal smooth muscles.
J Ethnopharmacol
; 68(1-3): 169-73, 1999 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-10624875
The effects of the methanolic extract of Acanthus montanus on different smooth muscle preparations have been investigated. The extract (6.25-100 microg/ml) produced a concentration-dependent relaxation and inhibition of the spontaneous contraction of the rabbit jejunum which was reversed by CaCl2 (0.1-1mM). This effect of the extract was not blocked by propranolol (3 x 10(-7) M) but partially antagonised by phentolamine (10(-6)-3 x 10(-6) M), procaine (10(-3) M) and methylene blue (10(-5) M). The extract also caused a concentration-dependent relaxation of the KCl-precontracted taenia coli of the guinea-pig which was partially blocked by propranolol (3 x 10(-5) M) that completely blocked isoprenaline (10(-8)-3 x 10(-4) M) relaxation of the tissue. Methylene blue (10(-5) M) and procaine (10(-3) M) completely blocked the direct relaxant effects of the extract and isoprenaline on the guinea-pig taenia coli. The extract (0.1-1mg/ml) shifted the concentration-response curves of CaCl2 to the right in a concentration-dependent manner on the guinea-pig taenia coli. These effects of the extract suggest a non specific smooth muscle relaxant activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Intestinos
/
Relajación Muscular
/
Músculo Liso
Límite:
Animals
Idioma:
En
Revista:
J Ethnopharmacol
Año:
1999
Tipo del documento:
Article
País de afiliación:
Nigeria
Pais de publicación:
Irlanda