The gene conversion hypothesis of MHC evolution: a review.

Martinsohn, J T; Sousa, A B; Guethlein, L A; Howard, J C

Martinsohn, J T; Sousa, A B; Guethlein, L A; Howard, J C.

Afiliación

Martinsohn JT; Institute for Genetics, University of Cologne, Zülpicher Strasse 47, D-50674 Cologne, Germany. jann.martinsohn@uni-koeln.de

Immunogenetics ; 50(3-4): 168-200, 1999 Nov.

Article en En | MEDLINE | ID: mdl-10602879

RESUMEN

Gene conversion is often invoked to explain the evolution of sequence patterns observed in major histocompatibility complex (MHC) genes and their alleles. This is the gene conversion hypothesis of MHC sequence evolution. These observations and their interpretation probably belong in a larger theoretical framework, namely the evolution of systems of resistance to rapidly evolving pathogens. This review looks critically at the evidence in favor of the gene conversion hypothesis in this context. We conclude that the case for the existence of an adaptive mechanism in the MHC favoring gene conversion mutations is not proven.

Asunto(s)

Evolución Molecular; Conversión Génica; Complejo Mayor de Histocompatibilidad/genética; Alelos; Secuencia de Aminoácidos; Animales; Secuencia de Bases; Humanos; Datos de Secuencia Molecular; Polimorfismo Genético; Homología de Secuencia de Aminoácido

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Evolución Molecular / Conversión Génica / Complejo Mayor de Histocompatibilidad Límite: Animals / Humans Idioma: En Revista: Immunogenetics Año: 1999 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

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