Incorporating larger families in identity-by-descent based linkage analysis.

Loesgen, S; Scholz, M; Schmidt, S; Bickeböller, H

Loesgen, S; Scholz, M; Schmidt, S; Bickeböller, H.

Afiliación

Loesgen S; Institute for Medical Statistics and Epidemiology, Technische Universität München, Germany.

Genet Epidemiol ; 17 Suppl 1: S235-40, 1999.

Article en En | MEDLINE | ID: mdl-10597442

RESUMEN

Genome scans for alcoholism susceptibility genes were carried out using identity-by-descent-based statistics for qualitative traits. We compared the results when 1) multipoint information was used for all families, where some had to be truncated, 2) multipoint information was used only for small families while large (untruncated) pedigrees were analyzed with a single-point approach, and 3) single-point analysis was used for all pedigrees. Differences between the methods were observed, but neither method could identify regions related to the susceptibility for alcoholism.

Asunto(s)

Alcoholismo/genética; Familia; Ligamiento Genético; Alcoholismo/epidemiología; Pruebas Genéticas; Genoma; Humanos; Análisis Multivariante; Carácter Cuantitativo Heredable; Programas Informáticos; Estadísticas no Paramétricas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Familia / Alcoholismo / Ligamiento Genético Tipo de estudio: Prognostic_studies / Qualitative_research Límite: Humans Idioma: En Revista: Genet Epidemiol Asunto de la revista: EPIDEMIOLOGIA / GENETICA MEDICA Año: 1999 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

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