Modification of acquired immunity in mice by imipenem/cilastatin.

Ortega, E; de Pablo, M A; Gallego, A M; Gaforio, J J; Alvarez, C; Ruiz-Bravo, A; de Cienfuegos, G A

Ortega, E; de Pablo, M A; Gallego, A M; Gaforio, J J; Alvarez, C; Ruiz-Bravo, A; de Cienfuegos, G A.

Afiliación

Ortega E; Department of Health Sciences, University of Jaén, Spain.

J Antimicrob Chemother ; 44(4): 561-4, 1999 Oct.

Article en En | MEDLINE | ID: mdl-10588322

RESUMEN

The immunomodulating properties of antimicrobial drugs may have important implications for clinical practice, particularly for those patients whose immune system has been compromised. In this study, we assessed the influence of different treatments with a beta-lactam antibiotic (imipenem/cilastatin) on several acquired immune responses of BALB/c mice; splenocyte responses to specific mitogens and to sheep red blood cells, IL-2 production and proportions of the different lympho-monocytic populations. Impenem/cilastatin was shown to modify some lymphocyte-associated immune functions and it would be useful to investigate whether immunomodulatory effects also occur in humans.

Asunto(s)

Quimioterapia Combinada/farmacología; Inmunidad/efectos de los fármacos; Animales; Cilastatina/farmacología; Combinación Cilastatina e Imipenem; Combinación de Medicamentos; Imipenem/farmacología; Interleucina-2/biosíntesis; Activación de Linfocitos/efectos de los fármacos; Masculino; Ratones; Ratones Endogámicos BALB C

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quimioterapia Combinada / Inmunidad Límite: Animals Idioma: En Revista: J Antimicrob Chemother Año: 1999 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido

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