Bcl10 in chronic lymphocytic leukaemia and T-cell prolymphocytic leukaemia.

Yuille, M R; Stone, J G; Bradshaw, P S; Houlston, R S

Yuille, M R; Stone, J G; Bradshaw, P S; Houlston, R S.

Afiliación

Yuille MR; Academic Department of Haematology and Cytogenetics, Institute of Cancer Research, Sutton, Surrey. myuille@icr.ac.uk

Br J Haematol ; 107(2): 384-5, 1999 Nov.

Article en En | MEDLINE | ID: mdl-10583229

RESUMEN

Bcl10 is a cancer gene recently identified in B-cell lymphomas of mucosa-associated lymphoid tissues. It has been suggested as a target for mutation in multiple types of tumour including follicular lymphoma, T-cell acute lymphoblastic leukaemia and Sezary syndrome. To evaluate further the role of Bcl10 in human adult haematological cancers, we screened for mutations samples from 24 patients with B-cell chronic lymphocytic leukaemia (CLL) and 18 samples from patients with T-cell prolymphocytic leukaemia (T-PLL). No pathogenic mutations were detected in any of the samples analysed, strongly suggesting that Bcl10 is not involved in the development of CLL or T-PLL and that its involvement may be restricted to other haematological malignancies.

Asunto(s)

Proteínas Adaptadoras Transductoras de Señales; Leucemia Linfocítica Crónica de Células B/genética; Leucemia Prolinfocítica/genética; Mutación/genética; Proteínas de Neoplasias/genética; Adulto; Proteína 10 de la LLC-Linfoma de Células B; Exones; Humanos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Linfocítica Crónica de Células B / Leucemia Prolinfocítica / Proteínas Adaptadoras Transductoras de Señales / Mutación / Proteínas de Neoplasias Límite: Adult / Humans Idioma: En Revista: Br J Haematol Año: 1999 Tipo del documento: Article Pais de publicación: Reino Unido

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