A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing.
Development
; 126(24): 5739-47, 1999 Dec.
Article
en En
| MEDLINE
| ID: mdl-10572049
The Drosophila EGF receptor (DER) is required for the specification of diverse cell fates throughout development. We have examined how the activation of DER controls the development of vein and intervein cells in the Drosophila wing. The data presented here indicate that two distinct events are involved in the determination and differentiation of wing cells. (1) The establishment of a positive feedback amplification loop, which drives DER signaling in larval stages. At this time, rhomboid (rho), in combination with vein, initiates and amplifies the activity of DER in vein cells. (2) The late downregulation of DER activity. At this point, the inactivation of MAPK in vein cells is necessary for the maintenance of the expression of decapentaplegic (dpp) and becomes essential for vein differentiation. Together, these temporal and spatial changes in the activity of DER constitute an autoregulatory network that controls the definition of vein and intervein cell types.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Quinasas
/
Alas de Animales
/
Transducción de Señal
/
Receptores de Péptidos de Invertebrados
/
Proteínas de Drosophila
/
Drosophila melanogaster
/
Receptores ErbB
Límite:
Animals
Idioma:
En
Revista:
Development
Asunto de la revista:
BIOLOGIA
/
EMBRIOLOGIA
Año:
1999
Tipo del documento:
Article
Pais de publicación:
Reino Unido