Human apolipoprotein A-IV reduces gastric acid secretion and diminishes ulcer formation in transgenic mice.

Vergnes, L; Baroukh, N; Léhy, T; Moizo, L; Bado, A; Baralle, M; Baralle, F E; Zakin, M M; Ochoa, A

Vergnes, L; Baroukh, N; Léhy, T; Moizo, L; Bado, A; Baralle, M; Baralle, F E; Zakin, M M; Ochoa, A.

Afiliación

Vergnes L; Unité d'Expression des Gènes Eucaryotes, Institut Pasteur, Paris, France.

FEBS Lett ; 460(1): 178-81, 1999 Oct 22.

Article en En | MEDLINE | ID: mdl-10571083

RESUMEN

We have investigated the involvement of human apolipoprotein A-IV (apoA-IV) in gastric acid secretion and ulcer formation in recently generated apoA-IV transgenic mice. Compared to control littermates, transgenic animals showed a gastric acid secretion decreased by 43-77% whereas only slight variations were observed in the different cell population densities within the gastric mucosa. In addition, no variation in gastrin levels was observed. Transgenics were protected against indomethacin-induced ulcer formation, with lesions diminishing by 45 to 64% compared to controls. These results indicate that endogenous apoA-IV expression can regulate gastric acid secretion and ulcer development.

Asunto(s)

Apolipoproteínas A/genética; Ácido Gástrico/metabolismo; Úlcera Gástrica/genética; Factores de Edad; Animales; Mucosa Gástrica/metabolismo; Gastrinas/metabolismo; Humanos; Indometacina/farmacología; Ratones; Ratones Transgénicos; Úlcera Gástrica/metabolismo; Úlcera Gástrica/patología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apolipoproteínas A / Úlcera Gástrica / Ácido Gástrico Límite: Animals / Humans Idioma: En Revista: FEBS Lett Año: 1999 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido

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