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Paeoniflorin reverses guanethidine-induced hypotension via activation of central adenosine A1 receptors in Wistar rats.
Cheng, J T; Wang, C J; Hsu, F L.
Afiliación
  • Cheng JT; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, ROC. jtcheng@mail.ncku.edu.tw
Clin Exp Pharmacol Physiol ; 26(10): 815-6, 1999 Oct.
Article en En | MEDLINE | ID: mdl-10549407
1. Intravenous injection of paeoniflorin, a glycoside purified from the root of Paeonia lactiflora, reversed guanethidine-induced hypotension in Wistar rats. 2. Pretreatment with the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine inhibited this effect of paeoniflorin in a dose-dependent manner. 3. The action of paeoniflorin was not modified by 8-(p-sulfophenyl)theophylline, the polar antagonist of the adenosine A1 receptor, which is not able to enter the central nervous system. 4. We conclude that paeoniflorin can reverse guanethidine-induced hypotension via activation of adenosine A1 receptors in the brain of Wistar rats.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzoatos / Hidrocarburos Aromáticos con Puentes / Antiinflamatorios no Esteroideos / Receptores Purinérgicos P1 / Adrenérgicos / Glucósidos / Guanetidina / Hipotensión Límite: Animals Idioma: En Revista: Clin Exp Pharmacol Physiol Año: 1999 Tipo del documento: Article Pais de publicación: Australia
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzoatos / Hidrocarburos Aromáticos con Puentes / Antiinflamatorios no Esteroideos / Receptores Purinérgicos P1 / Adrenérgicos / Glucósidos / Guanetidina / Hipotensión Límite: Animals Idioma: En Revista: Clin Exp Pharmacol Physiol Año: 1999 Tipo del documento: Article Pais de publicación: Australia