Immunochemotherapy for Leishmania donovani infection in golden hamsters: combinatorial action of poly ICLC plus L-arginine and sodium stibogluconate (Stibanate).
J Interferon Cytokine Res
; 19(10): 1103-6, 1999 Oct.
Article
en En
| MEDLINE
| ID: mdl-10547149
We demonstrate that golden hamsters infected with Leishmania donovani amastigotes develop the capacity to eliminate intracellular pathogens on treatment with low-dose standard antileishmanial sodium stibogluconate (Stibanate) in combination with polyinosinic-polycytidilic acid stabilized with polylysine and carboxymethycellulose (poly ICLC), a potent inducer of interferon (IFN) and immune enhancer, plus L-arginine. Data suggest that low doses of both Stibanate and poly ICLC plus L-arginine provide marginal inhibition against L. donovani infection in golden hamsters. When given in combination, however, a significant inhibition was achieved without toxicity, as all the animals survived up to 45 or 60 days. These results suggest that combination therapy using Stibanate and poly ICLC plus L-arginine may be very effective in reducing the dose of Stibanate and, hence, its dose-dependent toxicity in clinical situations.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polilisina
/
Leishmania donovani
/
Carboximetilcelulosa de Sodio
/
Inductores de Interferón
/
Poli I-C
/
Gluconato de Sodio Antimonio
/
Inmunoterapia
/
Leishmaniasis Visceral
Límite:
Animals
Idioma:
En
Revista:
J Interferon Cytokine Res
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Estados Unidos