[Pruritus in cancer: uncommon, but sometimes worse than the pain]. / Jeuk bij kanker: zeldzaam, maar soms erger dan pijn.
Ned Tijdschr Geneeskd
; 143(39): 1937-40, 1999 Sep 25.
Article
en Nl
| MEDLINE
| ID: mdl-10526610
Three patients, two females aged 45 and 56 years with metastasized breast carcinoma and one man aged 88 years with inoperable bronchial carcinoma, suffered from severe pruritus. This was only alleviated after treatment with paroxetine, a serotonin re-uptake inhibitor, or with tropisetron, a serotonin antagonist. The youngest woman then could be given chemotherapy, after which clinical recovery occurred, the other patients died, one week and 3 months, respectively, after start of the treatment. Pruritus is a relatively rare symptom in malignancies, but may be worse than pain. In the development and transmission of pruritus signals, in cholestatic icterus as well, serotonin appears to play a more important part than histamine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prurito
/
Antagonistas de la Serotonina
/
Neoplasias de la Mama
/
Carcinoma Broncogénico
/
Colestasis
/
Inhibidores Selectivos de la Recaptación de Serotonina
/
Paroxetina
/
Indoles
/
Neoplasias Pulmonares
Tipo de estudio:
Diagnostic_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Nl
Revista:
Ned Tijdschr Geneeskd
Año:
1999
Tipo del documento:
Article
Pais de publicación:
Países Bajos