[Value of intravenous immunoglobulins during antiphospholipid syndrome]. / Intérêt des immunoglobulines intraveineuses au cours du syndrome des antiphospholipides.
Rev Med Interne
; 20 Suppl 4: 410s-413s, 1999.
Article
en Fr
| MEDLINE
| ID: mdl-10522314
BACKGROUND: The antiphospholipid syndrome was individualized 12 years ago. Treatment was initially based on steroids, immunosuppressive drugs and intravenous immunoglobulin therapy. More recently, several retrospective studies have established that in most clinical conditions therapeutic doses of oral vitamin K antagonists (INR > or = 3) are sufficient to control the disease. THE ROLE OF IMMUNOGLOBULIN THERAPY: However, high dose immunoglobulin therapy is still indicated in a few cases, especially in life-threatening immune peripheral thrombocytopenia, and in recurrent foetal loss: in the latter indication, immunoglobulin therapy alone is efficient in 80% of cases. FUTURE PROSPECTS: Prospective studies are needed to assess the efficacy of intravenous immunoglobulin therapy in neurological complications occurring in spite of anticoagulant therapy, and in the context of repeated foetal losses when antithrombotic therapy with aspirin and subcutaneous heparin has failed.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulinas Intravenosas
/
Síndrome Antifosfolípido
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
Fr
Revista:
Rev Med Interne
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Francia