Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes.
FEMS Microbiol Lett
; 179(2): 233-9, 1999 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-10518721
Totarol is a diterpene compound extracted from the totara tree. Totarol and eight other diterpenes were found to potentiate methicillin, one reducing the minimum inhibitory concentration of methicillin against resistant Staphylococcus aureus 256-fold. Totarol did not inhibit the synthesis of DNA or peptidoglycan in S. aureus, but reduced the respiration rate by 70%. Under potentiation conditions, diterpenes had only a slight effect on the respiration rate, but had a significant effect on expression of PBP 2a. We conclude that the primary staphylococcal target for totarol is the respiratory chain, but that potentiation of methicillin by diterpenes is by interference with PBP 2a expression.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Peptidil Transferasas
/
Resistencia a la Meticilina
/
Diterpenos
/
Hexosiltransferasas
/
Meticilina
Idioma:
En
Revista:
FEMS Microbiol Lett
Año:
1999
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda
Pais de publicación:
Reino Unido