Methotrexate and misoprostol used alone or in combination for early abortion.
Contraception
; 59(6): 389-94, 1999 Jun.
Article
en En
| MEDLINE
| ID: mdl-10518234
ABSTRACT
PIP: A randomized controlled study was performed to assess the efficacy of intramuscular (im) methotrexate and vaginal misoprostol, either alone or in combination, for abortion among 108 women at 63 days¿ gestation or less. The subjects were those who had requested elective termination of pregnancy and medical abortion at 9 weeks¿ gestation or less and were randomized into three groups. Group 1 took 50 mg/sq. m im methotrexate on day 1 and a second dose was given if the human chorionic gonadotropin level had increased by 50% of the initial level on day 4. Weekly intervals were done until day 21. Group 2 took 800 mcg vaginal misoprostol on day 1 and a repeat dose was given if ultrasound showed a gestational sac on day 4. Reexamination was done on day 7. Group 3 took 50 mg/sq. m im methotrexate, which was followed 3 days later by 800 mcg vaginal misoprostol; subjects were reexamined on day 7. In group 1, complete abortion occurred in 69% of the subjects; in group 2, in 58% of the subjects; in group 3, in 89% of the subjects. Complete abortion rate was higher in group 3 than in groups 1 and 2. Therefore, the combination of methotrexate and misoprostol is a more effective abortifacient regimen than either drug is alone.
Palabras clave
Abortifacient Agents; Abortion, Drug Induced; Abortion, Induced; Asia; Biology; Clinical Research; Clinical Trials; Developing Countries; Drugs; Endocrine System; Family Planning; Fertility Control, Postconception; Mediterranean Countries; Methotrexate; Misoprostol; Physiology; Prostaglandins; Prostaglandins, Synthetic; Research Methodology; Research Report; Treatment; Turkey; Western Asia
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Abortivos no Esteroideos
/
Metotrexato
/
Misoprostol
/
Aborto Inducido
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Contraception
Año:
1999
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Estados Unidos