The penetration of anti-infectives into the central nervous system.

Kearney, B P; Aweeka, F T

Kearney, B P; Aweeka, F T.

Afiliación

Kearney BP; Clinical Pharmacology Fellow, Drug Research Unit, Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, California.

Neurol Clin ; 17(4): 883-900, 1999 Nov.

Article en En | MEDLINE | ID: mdl-10517933

RESUMEN

The blood-brain barrier, blood-cerebrospinal fluid (CSF) barrier, and meninges are a complex and difficult-to-study system charged with protecting the central nervous system (CNS) from toxins, including drugs. Current estimates of CNS drug exposure are limited to CSF to blood ratios, of which area-under-the curve (AUC) estimates provide the most robust measure of drug exposure. Different classes of drugs and individual drugs within classes have different CNS penetration potential that is dependent upon a variety of biologic and pharmacologic factors. Clinical data (AUC and point ratios) regarding the penetration of several anti-infective agents used for the treatment of CNS infections are provided in this article.

Asunto(s)

Antibacterianos/farmacocinética; Antivirales/farmacocinética; Encéfalo/metabolismo; Infecciones del Sistema Nervioso Central/tratamiento farmacológico; Humanos; Factores de Tiempo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Encéfalo / Infecciones del Sistema Nervioso Central / Antibacterianos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Neurol Clin Año: 1999 Tipo del documento: Article Pais de publicación: Estados Unidos

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