Dose and scanning delay using USPIO for central nervous system macrophage imaging.
MAGMA
; 8(3): 185-9, 1999 Aug.
Article
en En
| MEDLINE
| ID: mdl-10504046
RATIONALE AND OBJECTIVES: In experimental allergic encephalomyelitis (EAE), central nervous system (CNS) macrophage imaging is achievable by MRI using AMI-227 an ultra-small particle iron oxide contrast agent at a dose of 300 micromol/kg Fe. The objective was to test the feasibility at the human recommended dose of 45 micromol/kg Fe. METHODS: Two groups of EAE rats were tested with AMI-227 using 45 and 300 micromol/kg Fe respectively. Following i.v. injection of AMI-227, they were scanned after a delay of 4-6 and 20-24 h. RESULTS: With a high dose of AMI-227, all animals showed low signal intensity related to iron-loaded macrophages in the CNS. At low dose no abnormalities were found in the CNS. Furthermore, a delay of 4-6 h failed to demonstrate abnormalities even at high dose. CONCLUSIONS: Dose, scanning delay after administration and blood half-life are major parameters for T2* CNS macrophage imaging.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Óxidos
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Imagen por Resonancia Magnética
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Aumento de la Imagen
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Sistema Nervioso Central
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Encefalomielitis Autoinmune Experimental
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Hierro
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Macrófagos
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
MAGMA
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Alemania