Impaired Fas response and autoimmunity in Pten+/- mice.
Science
; 285(5436): 2122-5, 1999 Sep 24.
Article
en En
| MEDLINE
| ID: mdl-10497129
Inactivating mutations in the PTEN tumor suppressor gene, encoding a phosphatase, occur in three related human autosomal dominant disorders characterized by tumor susceptibility. Here it is shown that Pten heterozygous (Pten+/-) mutants develop a lethal polyclonal autoimmune disorder with features reminiscent of those observed in Fas-deficient mutants. Fas-mediated apoptosis was impaired in Pten+/- mice, and T lymphocytes from these mice show reduced activation-induced cell death and increased proliferation upon activation. Phosphatidylinositol (PI) 3-kinase inhibitors restored Fas responsiveness in Pten+/- cells. These results indicate that Pten is an essential mediator of the Fas response and a repressor of autoimmunity and thus implicate the PI 3-kinase/Akt pathway in Fas-mediated apoptosis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
Proteínas Serina-Treonina Quinasas
/
Apoptosis
/
Monoéster Fosfórico Hidrolasas
/
Receptor fas
/
Proteínas Supresoras de Tumor
/
Enfermedades Renales
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos