Detection of the T(14;18) translocation in follicle centre cell lymphomas in South African ethnic groups using PCR.

Essop, M F; Manuel, Y E; Close, P M

Essop, M F; Manuel, Y E; Close, P M.

Afiliación

Essop MF; Department of Anatomical Pathology, UCT Medical School, Observatory, South Africa. mfessop@chempath.uct.ac.za

Leuk Lymphoma ; 34(5-6): 609-13, 1999 Aug.

Article en En | MEDLINE | ID: mdl-10492087

RESUMEN

PCR was used to detect the t(14;18) translocation in 64 South African cases with follicle centre cell lymphoma. DNA was purified from paraffin-embedded tissue collected from different ethnic groups namely white, black and "mixed" race patients, and primers used to detect both mbr and mcr. The overall incidence of the translocation was 45%, which is similar to that of Caucasian and Chinese patients. The ratio of rearrangements occurring at the mbr and mcr was 7:1 which may be an overestimation. The ratio was three times higher for the "mixed" race group compared to whites, and this suggests that there may be ethnic variation in breakpoints in South African patients.

Asunto(s)

Cromosomas Humanos Par 14/genética; Cromosomas Humanos Par 18/genética; Linfoma Folicular/etnología; Linfoma Folicular/genética; Frecuencia de los Genes; Humanos; Reacción en Cadena de la Polimerasa; Grupos Raciales/genética; Sudáfrica/etnología; Translocación Genética/genética

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 14 / Cromosomas Humanos Par 18 / Linfoma Folicular Tipo de estudio: Diagnostic_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 1999 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Estados Unidos

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