Your browser doesn't support javascript.
loading
Carbohydrate-dependent hemolytic activity of the conjugate composed of a C-type lectin, CEL-I, and an amphiphilic alpha-helical peptide, 4(3)-beta Ala2.
Hatakeyama, T; Kamine, T; Konishi, Y; Kuwahara, H; Niidome, T; Aoyagi, H.
Afiliación
  • Hatakeyama T; Department of Applied Chemistry, Faculty of Engineering, Nagasaki University, Japan. thata@net.nagasaki-u.ac.jp
Biosci Biotechnol Biochem ; 63(7): 1312-4, 1999 Jul.
Article en En | MEDLINE | ID: mdl-10478460
A lectin-cationic peptide conjugate, 4(3)-CEL-I, was prepared from an invertebrate C-type lectin, CEL-I, and an amphiphilic alpha-helical peptide, 4(3)-beta Ala2 [Ac-(Leu-Ala-Arg-Leu)3-beta Ala2]. When 4(3)-CEL-I was incubated with rabbit erythrocytes, hemolysis was observed, especially at basic pH. Inhibition experiment using some carbohydrates suggested that hemolytic activity of 4(3)-CEL-I was caused by the interaction between 4(3)-beta Ala2 portion in the conjugate and the lipid bilayer after binding to the carbohydrate chains on the cell surface by the lectin activity of CEL-I.
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pepinos de Mar / Proteínas / Metabolismo de los Hidratos de Carbono / Hemólisis / Lectinas Límite: Animals Idioma: En Revista: Biosci Biotechnol Biochem Asunto de la revista: BIOQUIMICA / BIOTECNOLOGIA Año: 1999 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pepinos de Mar / Proteínas / Metabolismo de los Hidratos de Carbono / Hemólisis / Lectinas Límite: Animals Idioma: En Revista: Biosci Biotechnol Biochem Asunto de la revista: BIOQUIMICA / BIOTECNOLOGIA Año: 1999 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido