Ventilatory instability during sleep onset in individuals with high peripheral chemosensitivity.
J Appl Physiol (1985)
; 87(2): 661-72, 1999 Aug.
Article
en En
| MEDLINE
| ID: mdl-10444626
Previous work has shown that the magnitude of state-related ventilatory fluctuations is amplified over the sleep-onset period and that this amplification is partly due to peripheral chemoreceptor activity, because it is reduced by hyperoxia (J. Dunai, M. Wilkinson, and J. Trinder. J. Appl. Physiol. 81: 2235-2243, 1996). These data also indicated considerable intersubject variability in the magnitude of amplification. A possible source of this variability is individual differences in peripheral chemoreceptor drive (PCD). We tested this hypothesis by measuring state-related ventilatory fluctuations throughout sleep onset under normoxic and hyperoxic conditions in subjects with high and low PCD. Results demonstrated that high-PCD subjects experienced significantly greater amplification of state-related ventilatory fluctuations than did low-PCD subjects. In addition, hyperoxia significantly reduced the amplification effect in high-PCD subjects but had little effect in low-PCD subjects. These results indicate that individuals with high PCD are likely to experience greater sleep-related ventilatory instability and suggest that peripheral chemoreceptor activity can contribute to sleep-disordered breathing.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Respiración
/
Piel
/
Fases del Sueño
/
Células Quimiorreceptoras
/
Ventilación Pulmonar
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Appl Physiol (1985)
Asunto de la revista:
FISIOLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Estados Unidos