Is lithium able to reverse neurological damage induced by vinca alkaloids? (Short communication).
J Neural Transm (Vienna)
; 106(5-6): 569-75, 1999.
Article
en En
| MEDLINE
| ID: mdl-10443559
Lithium (Li) actively antagonises the inhibiting action of vinca alkaloids on human leukocyte chemotaxis; it proved to be related to the activation of microtubular system, possibly mediated by its inhibiting effect on cyclic AMP. Vinca alkaloids induce peripheral neuropathy and muscle damage. The molecular basis of this neurotoxicity has not been fully explained, but a possible role of neurofibrillary degeneration has been reported. We studied both in animals and in humans, whether Li is able to antagonise vinca alkaloid neurotoxicity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Reacción de Prevención
/
Vincristina
/
Carbonato de Litio
/
Sistema Nervioso Periférico
/
Trastornos Linfoproliferativos
/
Neurotoxinas
Límite:
Adult
/
Aged
/
Aged80
/
Animals
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Neural Transm (Vienna)
Año:
1999
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Austria