Comparison of vaginal misoprostol and gemeprost as pre-treatment in first trimester pregnancy interruption.
Br J Obstet Gynaecol
; 106(6): 540-3, 1999 Jun.
Article
en En
| MEDLINE
| ID: mdl-10426610
ABSTRACT
PIP: The effectiveness of vaginal misoprostol pretreatment in first-trimester abortion was compared with that of the standard gemeprost pretreatment regimen in a prospective randomized study conducted at Helsinki City Maternity Hospital (Finland) during 1996-97. 188 women scheduled for vacuum aspiration abortion were assigned to undergo cervical priming with a vaginally applied 200 mcg tablet of misoprostol for at least 4 hours (n = 95) or a 1 mg gemeprost vaginal suppository for at least 3 hours (n = 93). The mean duration of prostaglandin pretreatment was 221 minutes in the gemeprost group and 288 minutes in the misoprostol group. 14% of women in the gemeprost group and 5% in the misoprostol group needed pain medication. There were no uterine perforations, cervical ruptures, or incomplete evacuations in either group. Nausea and diarrhea were significantly more frequent in the gemeprost group. The effects of the two analogues were similar in terms of cervical softening, as determined by baseline cervical dilatation, and the presence of blood in the vagina. Overall, the misoprostol treatment was found to be as effective as the more costly gemeprost regimen, with even fewer side effects. Use of a 400 mcg vaginal dose of misoprostol could be considered to reduce the time required to reach peak plasma concentrations.
Palabras clave
Abortion, Induced; Biology; Cervical Dilatation; Comparative Studies; Developed Countries; Endocrine System; Europe; Family Planning; Fertility Control, Postconception; Finland; Misoprostol--administraction and dosage; Northern Europe; Physiology; Prostaglandins; Prostaglandins, Synthetic; Research Methodology; Research Report; Scandinavia; Studies; Treatment
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Abortivos no Esteroideos
/
Alprostadil
/
Misoprostol
/
Aborto Inducido
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Br J Obstet Gynaecol
Año:
1999
Tipo del documento:
Article
País de afiliación:
Finlandia
Pais de publicación:
Reino Unido