Successful postexposure rabies prophylaxis after erroneous starting treatment.
Prev Med
; 29(1): 28-31, 1999 Jul.
Article
en En
| MEDLINE
| ID: mdl-10419796
BACKGROUND: Postexposure prophylaxis, adequately applied after exposure to a rabid animal, is highly effective in prevention of human disease. Deviations from the recommended vaccination postexposure treatment protocol have been associated with vaccination failure and human mortality. We investigated an incident in which seven Israel Defense Forces soldiers were bitten by a rabid fox and initially treated not in accordance with the recommended vaccination protocol. METHODS: The soldiers received modified anti-rabies postexposure prophylaxis, including a higher dosage of both the active and the passive vaccines. The humoral antibody response was monitored subsequently. RESULTS: All soldiers showed a satisfactory increase (above 0.5 UE/ml by ELISA) in serum anti-rabies antibody titers. None developed the disease more than a year after follow-up. CONCLUSIONS: Strict adherence to the treatment guidelines following an injury by a rabid animal is of utmost importance. We suggest possible compensatory management after a potentially lethal deviation from protocol.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rabia
/
Mordeduras y Picaduras
/
Inmunoglobulinas
/
Vacunas Antirrábicas
/
Vacunación
/
Zorros
Tipo de estudio:
Guideline
Límite:
Adult
/
Animals
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Prev Med
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos