On the role of feedback in promoting conflicting goals of the adaptive immune system.

Segel, L A; Bar-Or, R L

Segel, L A; Bar-Or, R L.

Afiliación

Segel LA; Department of Computer Science and Applied Mathematics, The Weizmann Institute of Science, Rehovot, Israel. lee@wisdom.weizmann.ac.il

J Immunol ; 163(3): 1342-9, 1999 Aug 01.

Article en En | MEDLINE | ID: mdl-10415033

RESUMEN

We explored here the implications of two premises. 1) In their response over days or weeks to pathogen invasion, cells of the immune system combine several overlapping and perhaps contradictory goals. 2) The immune system has ways to monitor progress toward these goals via receptors that bind chemicals whose concentrations are related to such progress. We illustrate with simple mathematical models how such monitoring can lead to feedbacks that improve the efficiency of a given effector type in accomplishing its specialized task, and also how feedbacks can shift the balance among a variety of effectors toward a preponderance of the more effective. Specific suggestions are given for feedback molecules.

Asunto(s)

Sistema Inmunológico/inmunología; Inmunidad Innata; Infecciones/inmunología; Modelos Inmunológicos; Animales; Retroalimentación; Humanos; Modelos Teóricos

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Inmunológicos / Sistema Inmunológico / Inmunidad Innata / Infecciones Límite: Animals / Humans Idioma: En Revista: J Immunol Año: 1999 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links