[Systemic palliative chemotherapy with 5-fluorouracil and leucovorin in disseminated colorectal cancer]. / Systemisk pallierende kemoterapi med 5-fluorouracil og Leucovorin ved dissemineret kolorektal cancer.
Ugeskr Laeger
; 161(25): 3827-32, 1999 Jun 21.
Article
en Da
| MEDLINE
| ID: mdl-10412300
Systemic palliative chemotherapy is usually regarded as ineffective in disseminated colorectal cancer, and the risk of toxic adverse effects is often considered a contraindication, as many patients are old and cannot be offered curative treatment. Randomized trials during the last decade have shown, however, that an effect on both survival and quality of life can be expected. Only casuistic reports of total remission have been published but a partial tumour response can be expected in 20-50% of patients. Toxicity is related to palliative chemotherapy and accelerated with old age (> 70 years). When disseminated colorectal cancer is diagnosed the possibility of palliative chemotherapy should be conferred with an oncologist.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cuidados Paliativos
/
Neoplasias del Recto
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Leucovorina
/
Neoplasias del Colon
/
Fluorouracilo
/
Antimetabolitos Antineoplásicos
Tipo de estudio:
Clinical_trials
/
Systematic_reviews
Aspecto:
Patient_preference
Límite:
Aged
/
Humans
Idioma:
Da
Revista:
Ugeskr Laeger
Año:
1999
Tipo del documento:
Article
Pais de publicación:
Dinamarca