Role of Pax6 in development of the cerebellar system.
Development
; 126(16): 3585-96, 1999 Aug.
Article
en En
| MEDLINE
| ID: mdl-10409504
Post-mitotic neurons generated at the rhombic lip undertake long distance migration to widely dispersed destinations, giving rise to cerebellar granule cells and the precerebellar nuclei. Here we show that Pax6, a key regulator in CNS and eye development, is strongly expressed in rhombic lip and in cells migrating away from it. Development of some structures derived from these cells is severely affected in Pax6-null Small eye (Pax6(Sey)/Pax6(Sey)) embryos. Cell proliferation and initial differentiation seem unaffected, but cell migration and neurite extension are disrupted in mutant embryos. Three of the five precerebellar nuclei fail to form correctly. In the cerebellum the pre-migratory granule cell sub-layer and fissures are absent. Some granule cells are found in ectopic positions in the inferior colliculus which may result from the complete absence of Unc5h3 expression in Pax6(Sey)/Pax6(Sey) granule cells. Our results suggest that Pax6 plays a strong role during hindbrain migration processes and at least part of its activity is mediated through regulation of the netrin receptor Unc5h3.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cerebelo
/
Anomalías del Ojo
/
Proteínas de Homeodominio
/
Proteínas de Unión al ADN
Límite:
Animals
Idioma:
En
Revista:
Development
Asunto de la revista:
BIOLOGIA
/
EMBRIOLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
Reino Unido