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Leishmania: overexpression and comparative structural analysis of the stage-regulated meta 1 gene.
Uliana, S R; Goyal, N; Freymüller, E; Smith, D F.
Afiliación
  • Uliana SR; Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, UK.
Exp Parasitol ; 92(3): 183-91, 1999 Jul.
Article en En | MEDLINE | ID: mdl-10403759
The meta 1 gene of Leishmania major is upregulated in metacyclic promastigotes and encodes an 11.5-kDa protein with no significant similarities to other proteins in the existing databases. In this paper, we characterize the homologous meta 1 genes in L. amazonensis and L. donovani. Proteins encoded by this gene in all three species present a high degree of identity. The meta 1 gene cannot be replaced by gene targeting in L. major, suggesting an essential role for the protein, at least in promastigotes. Overexpression of the meta 1 protein in L. amazonensis generates parasites that are more virulent than wild-type organisms in vivo.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmania donovani / Leishmania mexicana / Proteínas Protozoarias Límite: Animals Idioma: En Revista: Exp Parasitol Año: 1999 Tipo del documento: Article Pais de publicación: Estados Unidos
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leishmania donovani / Leishmania mexicana / Proteínas Protozoarias Límite: Animals Idioma: En Revista: Exp Parasitol Año: 1999 Tipo del documento: Article Pais de publicación: Estados Unidos