Synthesis and analgesic activity of some condensed analogs of anpirtoline.

Rádl, S; Kovárová, L; Hezky, P; Vosátka, V; Königová, O; Proska, J; Krejcí, I

Rádl, S; Kovárová, L; Hezky, P; Vosátka, V; Königová, O; Proska, J; Krejcí, I.

Afiliación

Rádl S; Research Institute of Pharmacy and Biochemistry, Prague, Czech Republic.

Arch Pharm (Weinheim) ; 332(6): 208-12, 1999 Jun.

Article en En | MEDLINE | ID: mdl-10399490

RESUMEN

New condensed derivatives of anpirtoline, in which the pyridine ring is replaced with quinoline, isoquinoline, quinazoline, and phthalazine nuclei, have been synthesized. Their receptor binding profiles (5-HT1A, 5-HT1B) and analgesic activity (hot plate, acetic acid induced writhing) have been studied. The analgesic activity of compounds 7d, 8b, 8c, and 8e are at least comparable to that of the clinically used drugs flupirtine and tramadol under the same conditions.

Asunto(s)

Analgésicos/síntesis química; Piperidinas/síntesis química; Piridinas/síntesis química; Analgésicos/farmacología; Animales; Masculino; Ratones; Piperidinas/farmacología; Piridinas/farmacología; Ratas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Piridinas / Analgésicos Límite: Animals Idioma: En Revista: Arch Pharm (Weinheim) Año: 1999 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Alemania

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