Interplays between mouse mammary tumor virus and the cellular and humoral immune response.

Acha-Orbea, H; Finke, D; Attinger, A; Schmid, S; Wehrli, N; Vacheron, S; Xenarios, I; Scarpellino, L; Toellner, K M; MacLennan, I C; Luther, S A

Acha-Orbea, H; Finke, D; Attinger, A; Schmid, S; Wehrli, N; Vacheron, S; Xenarios, I; Scarpellino, L; Toellner, K M; MacLennan, I C; Luther, S A.

Afiliación

Acha-Orbea H; Ludwing Institute of Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland. hacha@eliot.unil.ch

Immunol Rev ; 168: 287-303, 1999 Apr.

Article en En | MEDLINE | ID: mdl-10399081

RESUMEN

Mouse mammary tumor virus has developed strategies to exploit the immune response. It requires vigorous immune stimulation to achieve efficient infection. The infected antigen-presenting cells present a viral superantigen on the cell surface which stimulates strong CD4-mediated T-cell help but CD8 T-cell responses are undetectable. Despite the high frequency of superantigen-reactive T cells, the superantigen-induced immune response is comparable to classical antigen responses in terms of T-cell priming, T-cell-B-cell collaboration as well as follicular and extra-follicular B-cell differentiation. Induction of systemic anergy is observed, similar to classical antigen responses where antigen is administered systemically but does not influence the role of the superantigen-reactive T cells in the maintenance of the chronic germinal center reaction. So far we have been unable to detect a cytotoxic T-cell response to mouse mammary tumor virus peptide antigens or to the superantigen. This might yet represent another step in the viral infection strategy.

Asunto(s)

Formación de Anticuerpos; Inmunidad Celular; Virus del Tumor Mamario del Ratón/inmunología; Infecciones por Retroviridae/inmunología; Infecciones Tumorales por Virus/inmunología; Secuencia de Aminoácidos; Animales; Células Presentadoras de Antígenos/inmunología; Antígenos Virales/inmunología; Humanos; Ratones; Datos de Secuencia Molecular; Superantígenos/inmunología; Linfocitos T/inmunología; Linfocitos T Citotóxicos/inmunología; Virosis/inmunología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Tumorales por Virus / Virus del Tumor Mamario del Ratón / Infecciones por Retroviridae / Inmunidad Celular / Formación de Anticuerpos Límite: Animals / Humans Idioma: En Revista: Immunol Rev Año: 1999 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido

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