Ethanol intake during lactation impairs milk production in rats and affects growth and metabolism of suckling pups.
Alcohol
; 18(1): 71-6, 1999 May.
Article
en En
| MEDLINE
| ID: mdl-10386668
From parturition, lactating Wistar rats were given 20% alcohol in drinking water and fed a solid diet ad lib (group AL). Pair-fed (PF) and control (C) rats were fed solid diet and given water ad lib (C). All animals were sacrificed on the 12th day of lactation. Ethanol treatment decreased food intake and milk production in lactating rats to a greater level than in PF rats, and a greater reduction in body weight of the AL pups was noted. Brain weight, protein concentration, and DNA content were also lower in pups of AL dams than of PF dams, whereas liver glycogen concentration was higher in the former. Pups from AL dams had higher circulating levels of beta-OH-butyrate, triglyceride, and free fatty acids than those from either C or PF dams. Plasma glucose concentration was lower in both PF and AL than in C pups, whereas the AL group had lower plasma protein concentration than any of the other groups. We conclude that maternal alcohol intake during lactation greatly impairs milk production, and although the known increase of lipid content in milk in rats studied under similar conditions allows an enhanced lipidic components in the pups, this adaptation does not allow normal growth and brain development.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Peso Corporal
/
Consumo de Bebidas Alcohólicas
/
Lactancia
/
Depresores del Sistema Nervioso Central
/
Etanol
/
Ingestión de Alimentos
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Alcohol
Asunto de la revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Año:
1999
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Estados Unidos