Zinc-alpha2-glycoprotein expression as a marker of differentiation in human oral tumors.

Brysk, M M; Lei, G; Adler-Storthz, K; Chen, Z; Brysk, H; Tyring, S K; Arany, I

Brysk, M M; Lei, G; Adler-Storthz, K; Chen, Z; Brysk, H; Tyring, S K; Arany, I.

Afiliación

Brysk MM; Department of Dermatology, University of Texas Medical Branch, Galveston 77555, USA. mibrysk@utmb.edu

Cancer Lett ; 137(1): 117-20, 1999 Mar 22.

Article en En | MEDLINE | ID: mdl-10376801

RESUMEN

Zinc-alpha2-glycoprotein (Znalpha2gp) is a soluble major histocompatibility complex homolog widespread in body fluids and in glandular epithelia; the authors recently demonstrated its presence in stratified epithelia. Znalpha2gp has been associated with tumor differentiation in breast cancers and other carcinomas. We compare here its gene expression in histopathologically graded oral squamous cell carcinomas and in their perilesional normals. Znalpha2gp levels are higher in the controls than in the tumors, and higher in well-differentiated tumors than in poorly differentiated ones. Markers of oral epithelial maturation (keratin K13 and involucrin) are less simply related to tumor histology.

Asunto(s)

Biomarcadores de Tumor/metabolismo; Carcinoma de Células Escamosas/metabolismo; Glicoproteínas/metabolismo; Neoplasias de la Boca/metabolismo; Proteínas de Plasma Seminal; Carcinoma de Células Escamosas/patología; Diferenciación Celular; Humanos; Neoplasias de la Boca/patología; Zn-alfa-2-Glicoproteína

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Glicoproteínas / Carcinoma de Células Escamosas / Biomarcadores de Tumor / Proteínas de Plasma Seminal Límite: Humans Idioma: En Revista: Cancer Lett Año: 1999 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda

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