Serpins in the Caenorhabditis elegans genome.
Proteins
; 36(1): 31-41, 1999 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-10373004
Data mining in genome sequences can identify distant homologues of known protein families, and is most powerful if solved structures are available to reveal the three-dimensional implications of very dissimilar sequences. Here we describe putative serpin sequences identified with very high statistical significance in the Caenorhabditis elegans genome. When mapped onto vertebrate serpins such as alpha1-antitrypsin, they suggest novel structural features. Some appear complete, some show extensive deletions, and others appear to contain only the C-terminal part of the known serpin fold, probably in partnership with N-terminal regions that have conformations unlike those of known serpins. The observation of such striking sequence similarity, in proteins that must have significantly different overall structures, substantially extends the structural characteristics of the serpin family of proteins.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Serpinas
/
Genoma
/
Caenorhabditis elegans
Tipo de estudio:
Health_economic_evaluation
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Proteins
Asunto de la revista:
BIOQUIMICA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Estados Unidos