A proven case of materno-foetal transfusion determined by cytogenetic and DNA analysis.

Paoloni-Giacobino, A; Dutoit, M H; Morris, M A; Dahoun, S P

Paoloni-Giacobino, A; Dutoit, M H; Morris, M A; Dahoun, S P.

Afiliación

Paoloni-Giacobino A; Division of Medical Genetics, Geneva University Hospital, Switzerland.

Clin Genet ; 55(4): 256-8, 1999 Apr.

Article en En | MEDLINE | ID: mdl-10361986

RESUMEN

We report a case of materno-foetal transfusion in a phenotypically normal male foetus after death in utero at the 35th week of gestation. We have used cytogenetic and polymerase chain reaction (PCR) microsatellite analysis to determine the presence of maternal cells in foetal blood collected by intracardiac puncture. In the intracardiac blood sample, maternal cells were estimated to comprise between 5 and 10% of nucleated foetal blood cells. When there is a suspicion of foetal genetic pathology, it is necessary to be aware that the foetal blood karyotype may be misrepresentative, as the analysed blood cells can indeed be of maternal origin.

Asunto(s)

Muerte Fetal; Transfusión Fetomaterna/diagnóstico; Adulto; Femenino; Transfusión Fetomaterna/mortalidad; Humanos; Cariotipificación; Masculino; Repeticiones de Microsatélite; Reacción en Cadena de la Polimerasa; Polimorfismo Genético; Embarazo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Muerte Fetal / Transfusión Fetomaterna Límite: Adult / Female / Humans / Male / Pregnancy Idioma: En Revista: Clin Genet Año: 1999 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Dinamarca

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