Fatal combined intoxication with new antidepressants. Human cases and an experimental study of postmortem moclobemide redistribution.
Forensic Sci Int
; 100(1-2): 109-16, 1999 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-10356779
Three cases are presented in which death was caused by suicidal intoxication with moclobemide in combination with a selective serotonin reuptake inhibitor. Both antidepressant drug types are considered to be relatively safe with regard to lethal overdose. However, the combination may cause the serotonin syndrome, a condition with a high mortality rate. In one of the cases, there was clinical information consistent with the serotonin syndrome, in the two other cases, there was no information of the clinical course. Postmortem redistribution of the selective monoamine oxidase inhibitor moclobemide was investigated in a rat model. Postmortem concentrations in blood from the vena cava and the heart were found to be in good accordance with antemortem concentrations. Postmortem concentrations in vitreous humour and various tissues were also measured. The apparent volume of distribution was calculated to be 0.95 +/- 0.10 l/kg, which is in the same range as that reported in man.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autopsia
/
Suicidio
/
Benzamidas
/
Inhibidores Selectivos de la Recaptación de Serotonina
/
Síndrome de la Serotonina
/
Modelos Animales de Enfermedad
/
Antidepresivos
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Forensic Sci Int
Año:
1999
Tipo del documento:
Article
País de afiliación:
Noruega
Pais de publicación:
Irlanda