A novel 45 kDa secretory protein from rat olfactory epithelium: primary structure and localisation.

Merkulova, M I; Andreeva, S G; Shuvaeva, T M; Novoselov, S V; Peshenko, I V; Bystrova, M F; Novoselov, V I; Fesenko, E E; Lipkin, V M

Merkulova, M I; Andreeva, S G; Shuvaeva, T M; Novoselov, S V; Peshenko, I V; Bystrova, M F; Novoselov, V I; Fesenko, E E; Lipkin, V M.

Afiliación

Merkulova MI; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.

FEBS Lett ; 450(1-2): 126-30, 1999 Apr 30.

Article en En | MEDLINE | ID: mdl-10350070

RESUMEN

cDNA clones encoding the 45 kDa protein were isolated from a rat olfactory epithelium cDNA library and their inserts were sequenced. The reconstructed protein sequence comprises 400 amino acids with a calculated molecular mass of 46,026 Da. A homology was revealed between the amino acid sequence of the 45 kDa protein and the proteins involved in the transfer of hydrophobic ligands. Using in situ hybridisation, the 45 kDa protein mRNA expression was detected in the layer of supportive cells of olfactory epithelium, apical region of trachea, surface layer of the ciliated bronchial epithelium in lung and in skin epidermis.

Asunto(s)

Mucosa Olfatoria/química; Proteínas/genética; Secuencia de Aminoácidos; Animales; Secuencia de Bases; Clonación Molecular; ADN Complementario/química; Hibridación in Situ; Datos de Secuencia Molecular; Proteínas/química; ARN Mensajero/análisis; Ratas; Mapeo Restrictivo; Alineación de Secuencia

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Mucosa Olfatoria Límite: Animals Idioma: En Revista: FEBS Lett Año: 1999 Tipo del documento: Article Pais de publicación: Reino Unido

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