The effect of bradykinin on central dopamine receptors.
Pol J Pharmacol Pharm
; 28(6): 673-8, 1976.
Article
en En
| MEDLINE
| ID: mdl-1034925
Bradykinin (BK) injected intraventricularly (ivc) at doses of 0.25-0.5 mug per rat potentiated the depth of fluphenazine catalepsy and depressed or abolished the symptoms of sterotypy produced by amphetamine or apomorphine. BK did not affect the level of dopamine (DA), but elevated the level of homovanillic acid in the brain, and accelerated DA turnover as measured by the rate of dopamine disappearance following treatment with alpha-methyltyrosine. The results suggest that BK inhibits the central dopamine structures by blocking the DA receptors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bradiquinina
/
Receptores Dopaminérgicos
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Pol J Pharmacol Pharm
Año:
1976
Tipo del documento:
Article
Pais de publicación:
Polonia