Immunopathological examination of esophagus as a useful criterion of cure in pemphigus vulgaris.
J Eur Acad Dermatol Venereol
; 12(2): 115-8, 1999 Mar.
Article
en En
| MEDLINE
| ID: mdl-10343938
BACKGROUND: We performed histopathological and immunopathological examinations of the esophagus in patients with pemphigus vulgaris during clinical remission. METHODS: In the group of 14 patients without serum antibodies, five were treated with low doses of steroids and cyclophosphamide (as maintenance treatment), while nine had already completed the therapy. RESULTS: In all five cases under maintenance treatment we found bound pemphigus antibodies in vivo. Acantholysis was present in two of these. In all nine non-treated patients, acantholysis and immunopathological findings were negative. CONCLUSIONS: Our studies reveal that the absence of bound 'pemphigus vulgaris' antibodies in the esophagus by immunological examination could be regarded as proof of complete cure and could be the decisive finding to stop pemphigus treatment.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pénfigo
/
Esófago
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Eur Acad Dermatol Venereol
Asunto de la revista:
DERMATOLOGIA
/
DOENCAS SEXUALMENTE TRANSMISSIVEIS
Año:
1999
Tipo del documento:
Article
País de afiliación:
Polonia
Pais de publicación:
Reino Unido