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Hb Chile [beta28(B10)Leu-->Met]: an unstable hemoglobin associated with chronic methemoglobinemia and sulfonamide or methylene blue-induced hemolytic anemia.
Hojas-Bernal, R; McNab-Martin, P; Fairbanks, V F; Holmes, M W; Hoyer, J D; McCormick, D J; Kubik, K S.
Afiliación
  • Hojas-Bernal R; Facultad de Medicina, Universidad de Chile, Departamento de Medicina Interna, Hospital Clinica San Borja-Arriaran, Santiago.
Hemoglobin ; 23(2): 125-34, 1999 May.
Article en En | MEDLINE | ID: mdl-10335980
Among the causes of life-long cyanosis are congenital methemoglobinemia due to M hemoglobins, congenital methemoglobinemia due to methemoglobin reductase deficiency, a small number of low oxygen affinity hemoglobins, and a small number of unstable hemoglobins that spontaneously form methemoglobin in vivo at an accelerated rate. We report an unstable hemoglobin with these characteristics that was observed in a family of indigenous (native American) origin living near Santiago, Chile. This variant has the substitution beta28(B10)Leu-->Met, unambiguously corresponding to the DNA mutation of CTG-->ATG in beta-globin gene codon 28.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemoglobinas Anormales / Anemia Hemolítica / Metahemoglobinemia Tipo de estudio: Risk_factors_studies Límite: Humans / Male / Middle aged País/Región como asunto: America do sul / Chile Idioma: En Revista: Hemoglobin Año: 1999 Tipo del documento: Article Pais de publicación: Reino Unido
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemoglobinas Anormales / Anemia Hemolítica / Metahemoglobinemia Tipo de estudio: Risk_factors_studies Límite: Humans / Male / Middle aged País/Región como asunto: America do sul / Chile Idioma: En Revista: Hemoglobin Año: 1999 Tipo del documento: Article Pais de publicación: Reino Unido