Dizocilpine attenuates streptomycin-induced vestibulotoxicity in rats.
Neurosci Lett
; 265(2): 71-4, 1999 Apr 16.
Article
en En
| MEDLINE
| ID: mdl-10327171
NMDA receptor mediated excitotoxicity contributes substantially to aminoglycoside antibiotic-induced cochlear damage. Since vestibular as well as cochlear hair cells have glutamatergic synapses, aminoglycoside-induced vestibulotoxicity may also have an excitotoxic component. This hypothesis was tested by examining the effects of the uncompetitive NMDA receptor antagonist dizocilpine on streptomycin-induced vestibulotoxicity. Streptomycin-treated rats exhibited almost complete destruction of sensory hair cells in the crista ampullaris, vestibular impairment in the drop test, and hyperkinesia. Concurrent treatment with dizocilpine not only rescued a substantial population of sensory hair cells in the cristae, but prevented the attendant hyperkinesis and vestibular impairments. These results indicate that excitotoxic mechanisms contribute to aminoglycoside-induced vestibulotoxicity and that NMDA antagonists may be useful in attenuating aminoglycoside ototoxicity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estreptomicina
/
Vestíbulo del Laberinto
/
Maleato de Dizocilpina
/
Antagonistas de Aminoácidos Excitadores
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Irlanda